Aggregation chimaeras
نویسندگان
چکیده
منابع مشابه
Polyclonal origin of pancreatic islets in aggregation mouse chimaeras.
In the present study, we have examined the origin and growth pattern of the beta cells in pancreatic islets, to determine whether a single progenitor cell gave rise to all the precursors of the islets, or if each of a few progenitor cells is the founder of a different islet, or if each islet is a mixture of cells originating from a pool of progenitor cells. Aggregation mouse chimaeras where the...
متن کاملPrenatal fate of parthenogenetic cells in mouse aggregation chimaeras.
Parthenogenetically activated BCF1 and fertilized BALB/c embryos were aggregated to form chimaeras. The fate of the parthenogenetic component was followed in the conceptus during the second half of gestation. The results indicate an early strong selection against parthenogenetic cells in the extra-embryonal part, which is presumably complete by term, and a weaker selective process in the embryo...
متن کاملClonal analysis of intestinal crypt populations in mouse aggregation chimaeras.
The epithelium of each individual intestinal crypt in adult mouse aggregation chimaeras is composed of cells of a single parental genotype (Ponder et al. 1985). Using a carbohydrate polymorphism recognized by Dolichos biflorus agglutinin as a strain-specific marker on entire sheets of intestinal mucosa, we have analysed the two-dimensional mosaic patterns of patches of the chimaeric intestinal ...
متن کاملInvestigation of variability among mouse aggregation chimaeras and X-chromosome inactivation mosaics.
Mouse aggregation chimaeras were produced by aggregating C3H/HeH and C3H/HeHa-Pgk-1a/Ws embryos. At mid-term the proportions of the two cell populations in these conceptuses and the X-inactivation mosaic female progeny of C3H/HeH female X C3H/HeHa-Pgk-1a/Ws male matings were estimated using quantitative electrophoresis of phosphoglycerate kinase (PGK-1) allozymes. The percentage of PGK-1B was m...
متن کاملFormation of viable chimaeras by aggregation between teratocarcinomas and preimplantation mouse embryos.
The formation of viable teratocarcinoma-adult chimaeras, by aggregation rather than by microinjection, is described. Aggregation chimaeras were produced using two pluripotential EC cell lines, PSA-1/NG-2 and PSA-4/TG12. The frequency and distribution of chimaerism were assessed, for the EC cells, in conceptuses recovered from in utero and in adults. In utero 37% of the morphologically normal co...
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ژورنال
عنوان ژورنال: Nature
سال: 1977
ISSN: 0028-0836,1476-4687
DOI: 10.1038/267084a0